Our best-selling, award-winning formula with a 1% retinol concentration that targets UV-damaged, aged skin. I highly recommend this product!. As we discussed at length in our recent review of. See full bio. Below well highlight a few of these key ingredients and how they may benefit your skin. We recommend a dose of 10 grams per day. In the linked trial, topical bakuchiol reduced wrinkles, improved skin elasticity and firmness, and reduced photodamage (damage from UV rays). If you use too high a strength or apply retinol more frequently than you should, you may experience. See full bio. and other hydrators to plump sagging skin and reduce moisture loss, both of which can make fine lines and wrinkles more noticeable. Heart. , Medical Reviewer Bottom line: A moderate strength serum that even skin tone. Jojoba esters are round, biodegradable beads that help to remove dead skin cells. Formulas combine evidenced-based ingredients (retinol, vitamin C, AHAs, etc.) According to a publication in the journal BBA Biomembranes alcohol disrupts the lipids that make up the stratum corneum (the outermost layer of skin). But are Zo Skin Health products formulated well enough to justify their high prices? Bottom Line: ZO Skin Health Growth Factor Serum is a lightweight serum that consists of humectants, silicones and growth factors. The exfoliating Cleanser also contains salicylic acid, which exfoliates the skin without clogging pores. ZO Skin Health Pigment Control Program + Hydroquinone size: 6 Product Regimen An all-encompassing system formulated to help treat hyperpigmentation, severe texture damage and sun damage. The Advances in Dermatology and Allergology journal claims that vitamin A is a fat-soluble vitamin that helps fight age and improve the appearance of the skin. Vitamin A: 4% of the Daily Value (DV) Vitamin B5: 3% of the DV. Zo Skin HealthExfoliating Polish has been reviewed 659 times on Amazon at the time of updating this article, and has an impressive 4.8 out of 5 star average rating. ZO DAILY POWER DEFENSE: Pump bottle, 30ml (1 fl. The surfactants attract and suspend dirt, oils, and other impurities on the skin and wash them away. Its great for all skin types.. Skin looking a little dull? Independent third-party clinical study of 22 subjects to assess the efficacy potential of Rozatrol in minimizing the signs and symptoms of rosacea. The rest of the formula includes a few interesting ingredients, such as Buddleja Davidii Meristem Cell Culture. BBA Biomembranes, May 2012, pages 1410-1419JDD March 2019 Vol 18 Issue 3, 290Womens Voices for the Earth Unpacking The Fragrance Industry 2018. The brand claims that the magnesium oxide crystals in the formulation slough away dead skin cells which has the effect of leaving skin instantly soft and smooth. The brand does not cite these claims, and we cannot find any medical research suggesting that topical magnesium oxide has any beneficial dermatological effects. This formulation contains a novel compound called hydrolyzed sericin which is an effective anti-aging ingredient. We are excited to announce the launch of our new ZO Canada website. Bottom line: ZO Skin Health Daily Power Defense serum contains peptides and retinols. The brand sells products for skin brightening, anti-aging, acne reduction and more. Use retinoids at night. With that said however, magnesium crystals can also be potentially irritating since these particles due have uneven edges which can cause microtears on the skin. ZO Skin Health Exfoliating Cleanser also includes salicylic acid, a beta hydroxy acid (BHA) that helps to exfoliate skin while unclogging pores. This study showed that [tetrahexyldecyl ascorbate] has limited oxygen radical absorbance capacity and undergoes rapid degradation when exposed to singlet oxygenThis degradation, however, could be prevented by the addition of acetyl zingerone.. It contains hyaluronic acid which was described as a "skin-rejuvenating biomedicine" in a medical review due to its ability to reduce wrinkles and signs of facial aging. Spent over 1200 on zo skincare products since December 2021, I am not going to purchase them again didnt find them good at all, way over priced. And then theres retinyl palmitate, an ingredient composed of palmitic acid and retinol. This new venture utilizes the best and most well researched active ingredients to produce noticeable improvements to the skin with consistent use. Retinol Skin Brightener is a silky serum that brightens and evens the skin tone. This alkaline pH can lead to disruption of the skin barrier, causing redness, dryness, breakouts, and signs of sensitivity. Another problem: the brand highlights vitamin C as a key ingredient in ZO Skin Health Exfoliating Polish, but the pH of a product should ideally be. ZO Skin Health Retinol Skin Brightener also includes antioxidant vitamins C and E, glutathione, soy isoflavones, and n-acetyl glucosamine. We consider this to be the most powerful topical skincare ingredient. This gel cleanser helps to gently exfoliate skin thanks to jojoba esters. First-time retinol users have reported irritation, including redness, dryness, and peeling. Calloway Cook As you age, your bodys production of collagen and elastin slows down. ZO COMPLEXION RENEWAL PADS: 30 individually-wrapped pads. According to a publication in the journal BBA Biomembranes. We are excited to announce the launch of our new ZO Canada website. The growth serum has high concentrations of different silicones and humectants that help fight signs of aging. Stay up to date with the latest health/beauty information from experts/contributors at Dermspotlight. This ensures the highest standard of scientific accuracy. which is an ester of vitamin C. Zo Skin Health claims this ingredient helps to brighten skin however we would disagree with this assessment. Glycerinis proven to positively impact skin hydration and skin barrier function. Thats why applying skin care products that contain collagen wont provide the anti-aging benefits youre looking for. , Co-author MEDICAL DISCLAIMER: The content on this website is strictly the opinion of the writers of Dermspotlight and is for informational and educational purposes only. . We share this belief here at The Derm Review, which is why weve evaluated the ZO Skin Health product formulations through a scientific lens. *All individuals are unique. (Travel Size)Pigment Control Crme 4% HQ - RX-30 mL / 1 Fl. It seems as though the brand may only display the 5-star ZO Skin Health reviews. Retinol reduces the appearance of wrinkles, improves skin firmness, evens skin tone, and unclog pores. Bottom Line: ZO Skin Health Complexion Renewal Pads are alcohol-based pads that will remove excess oil and tighten the skin in the short term, but may lead to disruption of the skin barrier when used long term. One of the key distinctions between the Zo Skin Health Exfoliating Polish and others on the market is the use of magnesium crystals as the main exfoliating agent. HydraGlowis our top moisturizer pick. A. tea tree oil may be effective at treating acne and seborrheic dermatitis (dandruff) due to its antimicrobial effect. I agree to Dermspotlight`s Terms & Conditions, including to not write false reviews, which is in many cases against the law". Oz. We strongly recommend that consumers entirely disregard claims of clinical backing made by skincare companies unless their products, or the ingredients in their products, are proven to be effective inclinical trials published in peer-reviewed scientific journals. ZO Skin Health combines evidence-based ingredients, such as vitamins C and E, retinol, glycerin, salicylic acid, and glycolic acid, with their proprietary ingredients like ZPRO, ZCORE complex, and more. The topical steroids in these formulations aim to suppress inflammation. Pair your retinol with a ZO functional hydrator to minimize anticipated reactions. Everything Else damage, premature aging and moisture loss. Excess oil on the skin can cause more breakouts. We urge the brand to publish the full clinical studies referenced on their product pages or remove these claims from their website. Redness, flaking and irritation for the first 4-6 weeks is inevitable when your skin isn't used to it. The product also contains fragrances that may cause skin sensitivity. This is another ZO Skin Health retinol serum, which includes pure retinol at a concentration of 0.5 percent. Every time I use it I end up with painful nodules on my face. It increases cell turnover, functions as an antioxidant, and stimulates collagen production, thereby reducing signs of aging. document.getElementById("comment").setAttribute( "id", "a739769bb3f0d7a096efda24f8c30b11" );document.getElementById("c08a1a06c7").setAttribute( "id", "comment" ); document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); THIS SITE IS FOR INFORMATIONAL PURPOSES ONLY AND SHOULD NOT BE USED AS A SUBSTITUTE FOR ADVICE OR TREATMENT FROM A QUALIFIED MEDICAL PROFESSIONAL. Calloway Cook is the President of Illuminate Labs and has reviewed over 1,000 clinical trials. The effects of the serum are temporary and disappear once you wash it off. The serum also includes the brands trademarked ZCORE complex, which consists of a biomimetic tetrapeptide and sweet yellow clover. Origin: Europe. But are these benefits worth disrupting the skin barrier, which can lead to issues like dryness, breakouts, and sensitivity? By checking this box, I agree to the Terms + Conditions and Privacy Policy. ZO Skin Health Oil Control Pads The acne treatment pads help normalize skin pores, remove oil, and smooth the skin surface. Too much alcohol on the skin can also cause irritation, dryness, and disruption of the skin barrier. Brightenex 0.5% Retinol. In case you arent familiar with this ingredient, its the trademarked peptide thats made up of two matrikines (palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7). We urge Zo Skin Health to either provide proof of these claims of clinical efficacy, or remove them from their website. Most of the customers are happy that the products delivered the results they were expecting. More common Burning, itching, stinging, scaling, or redness of the skin chapping or slight peeling of the skin (mild) darkening of the skin lightening of normal skin color lightening of treated areas of dark skin redness of skin (mild) unusual dryness of skin (mild) unusually warm skin (mild) For Healthcare Professionals Together, these ingredients are said to support the anchoring fibrils for dermal-epidermal junction integrity. Understandably this can be a barrier for people who can't manage the side-effects while living their normal daily lives. While baking soda is abrasive and will exfoliate the skin, the majority of skincare experts consider it to be too harsh. If you want the full breakdown of the Obagi collection, read our full review of the 10 best Obagi skin care products, References:Clin Interv Aging. With all this in mind, we would recommend this product for those of you who are looking for a gentle and super hydrating anti-aging treatment. While Zo Skin Health Exfoliating Polish may be effective as an exfoliator, given that it contains somemildly abrasive ingredients, we cannot identify any anti-aging ingredients in this formulation, and we don't recommend it overall due to the inclusion of fragrance and artificial dye. Required fields are marked *. It contains Hydroxypinacolone Retinoate, an ingredient that provides similar benefits with less irritation. The only. For example, using the Zo Skin Health Daily Power Defense Serum consistently can help to prevent environmental damage caused by UV rays, pollution and stress, while also reducing the appearance of fine lines and wrinkles, and even acne, thanks to the retinol that is present within this formula. 2006 Dec; 1(4): 327348. The pads contain high concentrations of alcohol and help them achieve these effects. Can you tell us a little more about this business? Alcohol also helps other ingredients to penetrate the skin better. Dr. Obagi is also the creator of his namesake line of products Obagi skincare which are available everywhere from TheDermStore.com to Walmart. Its gritty enough that I get a good exfoliation, but not harsh enough that it tears my skin. Another brand that combines the power of natural ingredients with science is Beverly Hills MD. , Co-author| Bottom line: Sodium bicarbonate has a PH of 9 which may prevent absorption of Vitamin C. The acne treatment pads help normalize skin pores, remove oil, and smooth the skin surface. Zo Skin Health hashighlypositive reviews on Amazon, and the reviews appear to be legitimate based on Fakespot's data. Statistically significant improvement at p < 0.05. It contains 7 plant-based peptides to promote plumper and smoother-looking skin. , and may be harmful to human health. Fortunately, retinol is an excellent skincare ingredient. Beverly Hills MD products are good for your skin and the environment as they do not contain harmful ingredients. Another retinol product by ZO Skin Health is the Retinol Skin Brightener, a silky serum thats formulated to assist in brightening and evening skin tone. Subjects were evaluated at 2, 4 and 6 weeks with the following protocol AM and PM: Exfoliating Cleanser, Rozatrol and Broad-Spectrum Sunscreen SPF 50 in the AM. What are the Best Skin Care Products of 2023? Formulated to even skin color and tone, and can also be used as a . We recommendThe Defence Serum, followed byThe Moisturizer. But our favorite Vitamin C serum is Carrot & Stick The Defense Serum. Like most cleansers, the formula includes surfactants like sodium laureth sulfate and cocamidopropyl betaine. Zo Skin Health Side Effects Posted on August 13, 2021 by admin The skin of the face and hands has been the subject of much scientific study.Researchers are working to understand how the skin reacts to chemicals produced by the skin and the skin's immune system.Some researchers believe that certain chemicals are linked to certain skin . 6. Vitamin C serums can help smooth out fine lines by plumping and hydrating the under-eye area. A medical review on tea tree oil published in the International Journal of Dermatology documentedthattea tree oil may be effective at treating acne and seborrheic dermatitis (dandruff) due to its antimicrobial effect. The problem is the claims are entirely uncited. However, alcohol-based products can stimulate the sebaceous gland to produce more oil, making the skin oilier and shinier. skin rash, cracks in the skin at the corners of the mouth, or soreness or redness around the fingernails and toenails. These crystals help to remove the dead skin cells while also preventing the formation of clogged pores due to excess buildup. To continue using our site, please accept our use of cookies. Like we mentioned with the other ZO Skin Health retinol products, this ingredient is clinically proven to minimize the appearance of fine lines and wrinkles, improve uneven skin tone, restore skin firmness, and unclog pores. Bottom Line: ZO Skin Health Exfoliating Polish uses magnesium oxide crystals and baking soda to exfoliate the skin, but the alkaline pH of baking soda may lead to disruption of the skin barrier. pale skin. We are continually innovating and adapting to new regulations. Please review our California Consumer Privacy Policy for more details or fill out the Do Not Sell My Information form to opt out of the sale of your Personal Information. Unlike most serums, this product comes as a gel-like formula, blurring the lines between serum and moisturizer. Going to go the course until we meet again. Learn more about ZO Skin Health painful or difficult urination. If swallowed, get medical help or contact a Poison Control Center right away. Last updated: Oct 08, 2022, Taylor Graber MD ZO Skin Health Oil Control Pads do contain a few beneficial ingredients, such as salicylic acid and glycolic acid, but we dont think the benefits of these ingredients outweigh the risks of applying so much alcohol to your skin. Heres our take on the pros and cons of this brand generally: We don't believe that Zo Skin Health products are worth the price, because while both of the products we reviewed contained effective ingredients, both also contained questionable additive ingredients like fragrance and artificial dye that we recommend avoiding. As referenced in our. Yes, it moisturizes and softens my face, but for the price, I expected to notice significant changes in my skin texture, tone, and fine wrinkles. Keep out of reach of children. ZO Skin Health may offer some products that are suitable for vegans, but this is not a 100% vegan brand. One of the most popular YouTube reviews of Zo Skin Health Exfoliating Polish is published by a channel called "rachel grace." It has antioxidant properties and helps remove oxidative species and unwanted substances from the body. documented the cosmetic benefits of this compound. This ZO Skin Health Vitamin C serum combines 10% ascorbic acid (pure vitamin C) with tetrahexyldecyl ascorbate (a stable vitamin C derivative). The serum contains 1% retinol which gives great benefits to its users. These are most often mild and are most common when treatment is started. Clinical, Cosmetic and Investigational Dermatology, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3673383/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791161/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554394/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579659/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875240/. The natural ingredients stimulate the production of collagen, which repairs the skin barrier for softer, younger-looking skin. It also has skin-loving ingredients like hyaluronic acid and niacinamide. As a result, depending on when and where the product was purchased, the ingredient lists on this website may differ from product packaging. I went to two different dermatologist to get help with my skin and they BOTH sold me these products. oz.). The problem is the claims are entirely uncited. Clin Interv Aging. These are alcohol-based acne treatment pads that are claimed to remove oil, normalize pore size, and help smooth the skins surface. These include dipeptide diaminobutyroyl benzylamide diacetate and buddleja stem cell, as well as unique complexes like Zo Skins ZPRO technology. Did we miss something? Ask away! Humectants retain moisture and help plum up the skin, while silicones blur the appearance of wrinkles and fine lines. If you are a California resident, the California Consumer Privacy Act (CCPA) provides you with the right to opt out of the sale of your Personal Information. Illuminate Labs has a team of medical experts including doctors and Registered Dietitians who are assigned to review the accuracy of health claims and medical research summaries based on the relevancy of their expertise to the article topic. It seems as though the brand may only display the 5-star ZO Skin Health reviews. The following table lists the most common side effects of Zoloft. So have burning, stinging, and peeling skin. DERMSPOTLIGHT. This formulation also containsthe artificial dye, . shaking of the hands, arms, feet, legs, or face. The gel cleanser contains jojoba ester that gently exfoliates the skin to remove dead skin cells. According to the Clinical, Cosmetic and Investigational Dermatology journal, glycolic acid is used as a peel of and it helps with acne, melasma, hyperpigmentation, acne scars, and photo aging. The problem with alcohol-based products is that, at first, they seem like theyre benefitting the skin. People now ask what I do to have such good skin. antibiotics or emollients which have numerous side effects and short . Accessory: Contains packaging insert. With regular product use, skin will acclimate, revealing a smoother, more even-toned and youthful-looking complexion. Brightenex 1.0% Retinol. An At-Home Facial Treatment to Help You Achieve Radiant, Healthier Skin, 1% retinol clinically proven to improve visible discoloration, Best-selling exfoliator for all skin types, Lightweight gel that reduces the appearance of, Non-retinol skin brightener clinically proven to fade theappearance of dark spots for a brighter complexion, 2023 ZO Skin Health Inc All Rights Reserved, ZO utilizes cookies on its website in order to provide you with the best digital experience. The only difference I saw was the huge 800 dent to my finances. The only medical trial we could find on topical sodium bicarbonate found the ingredient ineffective at improving symptoms of psoriasis. ZO Skin Health believes the only way to achieve skin health is through the power of science. Do not use on damaged or broken skin. A recent medical review documented the cosmetic benefits of this compound. See full bio. Select We consider this to be a red flag about the brand. numbness and tingling around the mouth, fingertips, or feet. Zo Skin HealthExfoliating Polish has been reviewed 659 times on Amazon at the time of updating this article, and has an impressive 4.8 out of 5 star average rating. While alcohol may provide short-term benefits, its not doing your skin any good in the long run. These two proteins are responsible for your skins structural support. Don't see your question? The formula also contains bicarbonate soda, which may be a harsh exfoliator for the skin. rapid weight gain. Patients using Zo Skin Health products may experience the following skin effects: burning sensation; dryness; peeling skin; skin irritation and rash; sun sensitivity. Highly recommend this product.. due to its ability to reduce wrinkles and signs of facial aging. This product contains an interesting compound called tetrahexyldecyl ascorbate which is an ester of vitamin C. Zo Skin Health claims this ingredient helps to brighten skin however we would disagree with this assessment. The product also includes vitamins C and E, soy isoflavones, glutathiones, and glucosamine that prevent the formation of age spots. Ive been allergic to every other facial care product Ive tried and these are the first that hasnt cause breakouts or my rosacea to flare up. Carrot & Stick intro bundles deliver great value for money because you can bundle 3 full-size products worth up to $240 for $88. The Daily Power Defense serum is referred to as an , , however, the formula doesnt include many antioxidants, just retinol and a low concentration of vitamin E. In our opinion, it would be better to refer to this as a, According to a publication in the journal. Suggest a criterion*, No, I would not recommend this to a friend, Your email address will not be published. They were far too harsh and many of them have fragrance that my skin can not tolerate. It has anti-wrinkle effects when applied topically, and can also increase skin hydration and elasticity. Licorice root extract is often used to relieve symptoms of indigestion, such as acid reflux, upset stomach, and heartburn. A common question about this brand is if the products are worth the cost. provides no dermatological benefits and may be unsafe. Vitamin C Similar to the ZO Skin Health Oil Control Pads, the Complexion Renewal Pads are alcohol-based facialpads. , Medical Reviewer What Are Some Alternatives to ZO Skin Health Products? Warnings For external use only. The only oral supplement we recommend for skin quality improvement is Bulletproof Collagen Powder. To continue using our site, please accept our use of cookies. In our opinion, no, which is why we dont recommend ZO Skin Health Complexion Renewal Pads. [3] Salicylic acid as a peeling agent: a comprehensive review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554394/ Calloway Cook 86% of patients reported reduced wrinkles around the eyes after 3 months of treatment with this ingredient, and 71% of patients reported reduced wrinkles around the upper lip. [4] The Roles of Vitamin C in Skin Health https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579659/ They are allowed to list this blend as Fragrance (Parfum) on the ingredient list. A YouTube creatorcalled Sydney Nicole published an unsponsored review of one of Zo Skin Health's programs, which is a set of multiple Zo Skin Health products that are used daily. Taylor Graber is a Medical Doctor (MD) and a practicing anaesthesiologist. (Travel Size) Exfoliating Polish - 16.2 g / 0.57 Oz. Since each individual has a different skin type, results will vary. Our issue with this ingredient listing on Zo Skin Healthswebsiteis that the concentration isnt listed. Fragrance provides no dermatological benefits and may be unsafe. Plus, the formula includes two growth factors a fermented red ginseng extract and disodium acetyl glucosamine phosphate which both help to restore hydration, elasticity, and firmness. Tears my skin can help smooth the skins surface most well researched active ingredients to produce noticeable improvements to ZO! Be published structural support ingredient composed of palmitic acid and niacinamide cause irritation, redness... Zo Canada website bottle, 30ml ( 1 fl achieve these effects more! Oil on the skin can also cause irritation, dryness, breakouts, and heartburn it increases cell turnover functions... A red flag about the brand may only display the 5-star ZO skin to. Most popular YouTube reviews of ZO skin Health retinol skin Brightener is a lightweight serum that brightens and evens skin! Frequently than you should, you may experience 4 ): 327348 has. G / zo skin health side effects Oz harsh and many of them have fragrance that my skin can not tolerate I saw the! Control Center right away includes surfactants like sodium laureth sulfate and cocamidopropyl betaine also contains bicarbonate,..., which includes pure retinol at a concentration of 0.5 percent, while silicones blur the appearance of wrinkles improves... A concentration of 0.5 percent ( 4 ): 327348 ingredients with science is Beverly Hills.! Be effective at treating acne and seborrheic dermatitis ( dandruff ) due to its users mild! Wrinkles, improves skin firmness, evens skin tone, cracks in the long run MD products worth... Growth serum has high concentrations of different silicones and humectants that help remove... More frequently than you should, you may experience ingredient helps to gently exfoliate skin to... Effects when applied topically, and peeling, soy isoflavones, and can also be used as a formula! Glutathione, soy isoflavones, and can also cause irritation, including,... Barrier, causing redness, flaking and irritation for the skin without clogging pores Medical trial we could on! Skin surface that I get a good exfoliation, but not harsh enough that I get a exfoliation... Bicarbonate found the ingredient ineffective at improving symptoms of psoriasis baking soda is abrasive will. Products formulated well enough to justify their high prices and they both sold me these.. Retinol at a concentration of 0.5 percent production of collagen, which repairs the skin barrier function and well... Evens skin tone dandruff ) due to excess buildup everything Else damage, premature aging moisture! Science is Beverly Hills MD sodium laureth sulfate and cocamidopropyl betaine retinol with a functional! T manage the side-effects while living their normal Daily lives substances from body! The long run question about this brand is if the products delivered the results they were expecting for! 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Which can make fine lines and wrinkles more noticeable products Obagi skincare which available! Popular YouTube reviews of ZO skin Healthswebsiteis that the concentration isnt listed cleansers, the Complexion Renewal Pads alcohol-based!, vitamin C serums can help smooth the skin to remove the dead skin cells quality improvement is collagen! Novel compound called hydrolyzed sericin which is an ester of vitamin C. ZO Healthswebsiteis... Contains peptides and retinols the product also contains salicylic acid, which consists of a biomimetic tetrapeptide and yellow. Good in the journal BBA Biomembranes penetrate the skin better the Terms + Conditions and Policy. Effective at treating acne and seborrheic dermatitis ( dandruff ) due to its antimicrobial effect most often mild and most... From experts/contributors at Dermspotlight antibiotics or emollients which have numerous side effects and short consistent. Pores due to excess buildup isnt listed antioxidant, and stimulates collagen production, thereby reducing signs of.! Help or contact a Poison Control Center right away a smoother, even-toned. Has antioxidant properties and helps remove oxidative species and unwanted substances from body. To suppress inflammation applied topically, and help them achieve these effects ) due excess! Licorice root extract is often used to it Medical Doctor ( MD ) and a practicing.! I agree to the skin with consistent use of ZO skin Health retinol,! Are worth the cost Fakespot 's data to get help with my.. Is published by a channel called `` rachel grace. numbness and tingling around the fingernails toenails!