Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. When I went back for a second blood draw, they took two tubes of blood. E@Gpc 8Op!ISHiT7{;-N/OM7Mq+YV1d)|\i-V;`]tyTAHqAFWR I have a CVS booked for this Thursday which should give me definitive results but both scans didnt look good so far. Now at 16w they were both under 2. Note that once you confirm, this action cannot be undone. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. I can tell you that if you don't want to wait, the sneak peek test still works just fine if you can afford it. Check with your insurance provider before testing to be sure. Has anyone had the test come out inconclusive twice? Learn more about, Twins & Multiples: Your Tentative Time Table. NIPT stands for noninvasive prenatal testing. I dont have any advice. I had to do the NIPT test twice. I found out we are having a little girl! Unlike most DNA, which is found inside a cell's . Have the CVS tomorrow and should have definitive results 3 workings days later. My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didn't tell me over the phone what it was. Your healthcare provider can answer any questions you have, but ultimately you have to decide how a genetic or chromosomal disorder affects you and your family based on your situation. The results will be on this week for a few things but up to 2 weeks for everything. The test is slightly less accurate for detecting trisomy 18 and 13. Have had an earlier screening test that suggests a potential problem. I had the first done at 13w and second done at 16w. I'll be around 18 weeks by then. Inconclusive NIPT results twice - Page 2: hello, just wondering if this has happened to anyone? Strangely enough, I am also on lovenox.I am also old at 39 and have a higher BMI. There is a 0% chance of survival with this condition so we are looking into terminating in the next few days not my rainbow baby after all.. It just depends on the baby. However my 12 weeks NT scan and EFTS blood test both came back normal/ low risk for . Screening for sex chromosomes can help predict the sex of the fetus and can also screen for differences in the usual number of sex chromosomes. I dont think Im obese but definitely cons. It might be more trouble than it's worth to do a third draw, esp with a different company, but I thought I'd mention it so that you know it's potentially an option. We had an early anatomy scan which they said everything looked great but I just dont understand how I can have no testing results. Get useful, helpful and relevant health + wellness information. I've had he NIPT test twice now and had it come back for low fetal DNA. I also did NIPT twice and bouth times it came back inconclusive due to low fetal fraction. They could well be inaccurate- most companies require at least 3%. if you need any resources theres an amazing support group I terminated at 20 weeks for serious brain anomalys in June. I'm traveling and out of city for 3 weeks so I cant even rush to a clinic and get a private ultrasound to see if everything is ok. The stresfull part is that they suggest that low fetal fraction can be liked to trosimies.. NIPT Sex chromosome aneuploidy or fetal sex inconclusive You recently had a blood test to screen for chromosome disorders in the fetus and were told: amount of DNA is from the pregnancy. Just wanted to share my experience since Ive gotten both a CVS and an amniocentesis in the last 3 weeks.Backstory: at my 12 week nuchal translucency scan, we had a high measurement of nuchal fluid (3.5mm). A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. However, she didnt seem too concerned and said we will check things out at my anatomy scan, which is November 23rd. Yes, NIPT can predict the sex of the fetus. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. I am assuming they will suggest more invasive testing? My next appt is my anatomy scan and it isnt until Nov 30! (https://pubmed.ncbi.nlm.nih.gov/26781507/), Visitation, mask requirements and COVID-19 information. Cleveland Clinics Ob/Gyn & Womens Health Institute is committed to providing world-class care for women of all ages. The NIPT looks at these fragments of fetal DNA in your blood known as cell-free DNA or cfDNA. Thank you! If youre having a difficult time or wish to discuss the screenings in more detail, a genetic counselor can help you understand the prenatal testing options and what may be a good fit for you. Does knowing this information make me sad, anxious or feel prepared to care for the baby? Fortunately got low risk for chromosomal anomalies Just the baby's sex was inconclusive! Remember, only you and your family can decide whats best for you. Most NIPT tests screen for: An extra chromosome causes Down syndrome, trisomy 18 and trisomy 13. This just proves that getting inconclusive results doesnt always mean something is wrong. Friend opening my baby items for their own baby. I wish you well mama! I have been so scared the last 2 weeks thinking about this because theres really been a lack of info about what this could mean from my doctors office. However, for some unknown reason the lab decided to send my first sample from 12 weeks out to a specialist instead. When I called for test results over a week later, they said they had needed to test the second tube as the first had failed. yeah I declined the redraw also and decided to wait. In Latvia we have to do first trimester screening where they mesure NT and check Papp-a & HCgb levels. They didn't even bother to retest mine when the first try came back inconclusive because they assumed it wouldn't work since I'm obese. Both said due to low fetal DNA at 2.6% and 2.7% respectively. Im waiting for those NIPT results and still have two weeks to go before my anatomy scan. Just want to complain somewhere. Husband upset I dont want his family to visit for at Why do so many women like to give birth without medication? On top of the insufficient fetal fraction, I have been spotting on and off, which is one of the reasons I had been so stressed about the genetics testing.. wanting to make sure something wasnt wrong with baby. I have read this is an issue for plus size women and the other factor is age. It's not like my weight was a surprise to them. Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. the most helpful and trustworthy pregnancy and parenting information. *_xCeEm Di?z&>#m`X_ )=
I believe my test is from Natera and our genetic counselor said this company has higher rates of low fetal fraction. My OB did mention it as a possibility but I had heard of those with higher BMIs getting results, so I thought it might be okay. Accuracy of noninvasive prenatal testing using cell-free DNA for detection of Down, Edwards and Patau syndromes: a systematic review and meta-analysis. Out of curiosity I contacted this particular clinic for clarification and they told me that they write this on many patents NIPT. (https://medlineplus.gov/genetics/understanding/testing/nipt/). I am so confused and stressed. Please whitelist our site to get all the best deals and offers from our partners. She made it seem like I would definitely get the chance for a second blood draw at a later date and it would almost certainly work. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Has anyone had this happen to them or know someone? Unfortunately, my nuchal translucency came back bad and I am going to have to have an amniocentesis because of the failure of the NIPT to give me the information I needed, therefore raising my risk. also people mentioned placenta issues above! Lol. Oh yes I was referring to a blood test but thank you so much for the input. 2005-2023Everyday Health, Inc., a Ziff Davis company. This educational content is not medical or diagnostic advice. Really sending you love and support. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. I'm so frustrated that I'm too flipping fat to find out my baby's risk of certain disorders. The #1 app for tracking pregnancy and baby growth. I just did a retest last week because mine came back inconclusive!! Your test result shows that your pregnancy is at low risk for these three conditions. My doc told me 2 inconclusive tests raises the risk level significantly in my age. I agree with PP. Thats a good sign that your embryo is normal! For example, you may get a positive or high-risk result for trisomy 13 but a negative or low-risk result for Down syndrome. Were having a boy! This is called the fetal fraction. Overwhelmed and frustrated by weight gain. I did an amnio today. I am very plus size and this did happen to me during my last pregnancy but they got results on the second redraw. your experiences with being fat an needing IVF/ICSI? Im going for my ultrasound next Wednesday and Im kind of nervous. (https://www.smfm.org/publications/183-cell-free-dna-screening-is-not-a-simple-blood-test#:~:text=The%20Society%20for%20Maternal%2DFetal%20Medicine%20has%20stated%20that%20all,as%20pregnancy%20termination%2C%20is%20undertaken.). n_qTz Reddit and its partners use cookies and similar technologies to provide you with a better experience. I did IVF and my embryo was a normal embryo through pgt so that gives me hope. Inconclusive NIPT result twice w wjhall I received a phone call from my midwife today and she informed me that my second Panorama test can back inconclusive due to low fetal fraction. That is what the clinic told me. Mumsnet carries some affiliate marketing links, so if you buy something through our posts, we may get a small share of the sale (more details here). My doc told me 2 inconclusive tests raises the risk level significantly in my age. NIPT tests dont diagnose conditions. I was also severely anemic and dehydrated due to hyperemesis gravidum. My nipt/panorama/harmony results came back inconclusive both times. Diagnostic tests give a definitive answer about whether the fetus has a specific condition. Please specify a reason for deleting this reply from the community. Babies can be born with a change (https://www.nichd.nih.gov/health/topics/preconceptioncare/conditioninfo/tests-needed). Ocean/sky themed baby girl nursery - finished at 38+ A hilarious moment that made me excited to have my kid. I hate the thought of ending your babys life especially if the doctors have it wrong. We had two failed harmony results, both came back inconclusive because of low dna fraction. We discussed the option of additional genetic testing and amnio but since the ultrasounds hadnt shown any signs of concern we decided to try the 3rd round of genetic testing using Myriad. Can I ask how your Quad screening went? We strive to provide you with a high quality community experience. Also at 13w3days I had my. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. It's a boy and all looks well right now, so we'll just keep working to stay healthy and keep him growing. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Please specify a reason for deleting this reply from the community. The test can also determine the sex of the fetus. 107 0 obj
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Hi all, just an update. My anatomy ultrasound is on Friday. Is this an ivf pregnancy? It just means they don't have enough information to make any kind of conclusion. I had my anatomy scan in December and baby is very healthy and measuring on time! - September 2021 Birth Club - BabyCenter Canada Home Community September 2021 Birth Club Inconclusive NIPT twice! HW[o[~G~ mHc}pHV"=. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Im going through the exact same. Are you doing the NT scan & bloods as well? Your healthcare provider will discuss all your prenatal screening options, including NIPT. Eleniada 29/03/21 Has anyone had NIPT come back inconclusive twice??? We had issues with our genetic testing as well and I too was super worried! Inconclusive on gender results? Low Fetal Fraction. K/!0p8v?vbs#.TOc %>.n>pJKps,m0T7-r*Y:p
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RU'^G'ulAI$EW0]_.6L8Le. The test can also determine the sex of the fetus. 2005-2023Everyday Health, Inc., a Ziff Davis company. Just want to complain somewhere. NIPT testing can be done as early as 10 weeks of pregnancy through delivery. I have an early anatomy scan on Wednesday with an MFM due to my history of GD and age. Create an account or log in to participate. I will likely decline invasive testing like amniocentesis. Diagnostic testing may be recommended after you get NIPT test results. I've seen a few posts about on this sub from women who had insufficient fetal DNA because of their weight and had to go back for another draw. Mine came back inconclusive also. Both said due to low fetal DNA at 2.6% and 2.7% respectively. Myriad is able to magnify the fetal fraction found in your blood.. Basically they know I am coming back for the anatomy scan and the radiologist attempted to do a mini anatomy off the scans the technician got but that either the baby wasnt in the proper spot or it was too soon to make those comments until I am 20 weeks. Dont be afraid to ask questions. Its done by taking a sample of your blood, which also contains fragments of DNA from the fetus. However, its now recommended that providers offer NIPT to all pregnant people, regardless of risk. It seems awfully low, but hopefully the quad screen will be okay and the anatomy scan is next week. My doctor told me to test then and acted as if that wasnt too early. It took 6 weeks and a lot of worry, so ask for the SAFE if they have it? I also have this which is why Im on aspirin - here in the lu they check your blood at 12 weeks to find out about your placenta ! Note that once you confirm, this action cannot be undone. Praise post for amazing husbands and good in-laws. Are there other tests I can take to find out my risks? A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. NIPT is about 99% accurate in detecting Down syndrome. Your test results may sometimes be hard to interpret, so ask your healthcare provider for help if youre unsure. I dont understand why it didnt work for me. Now it is considered high risk and listed a 1/17 chance of a chromosome issue. So I just found out that my NIPT came back with low fetal fraction for the second time. Also I think there's a decent chance at identifying sex at 16 weeks - I had a limited anatomy scan at 13 weeks and the tech said she felt 80% confident identifying one but no clue on the other twin. We offer women's health services, obstetrics and gynecology throughout Northeast Ohio and beyond. Inconclusive NIPT twice? I was annoyed and asked why they didn't ask me to come back for another scan. We were told they were inconclusive due to low fetal fraction and ended up doing a CVS. Another inconclusive result. I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. The NIPT measures the fetal cfDNA in the mother's bloodstream, which comes from the placenta. Last reviewed by a Cleveland Clinic medical professional on 10/12/2022. Ultimately, we learned we were having a baby girl who did not test positive for trisomy but have still been advised to do an amniocentesis procedure at 16 weeks for ultimate peace of mind. Your healthcare provider will receive your test results first, then share the results with you. In all of the above to think thats the reason it didnt work for me do you have a low Papp-a? I am going to redraw at 15 weeks and fingers crossed I get a more definitive result. But how often do these tests fail to provide results, and what might such a result mean? :). I am so sorry this has happened twice! Your cells are constantly dividing and creating new cells. Find advice, support and good company (and some stuff just for fun). Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. I also felt stressed out between my ultrasounds because a low fetal fraction can also be an indication of trisomy 13 or 18. They could have also just waited until 16 weeks for my first blood draw given my weight. Which is less than it would normally be for my age. My first pregnancy resulted in a miscarriage at 8 weeks. Has anyone experienced this? At this point I am 20w, yes it can be - t13 & t18 but it can be linked to a lot of things! We then did the SAFE nipt as it needs roughly 0.5 dna fraction, where as other nipt tests need at least 4.5% and we got a result!! Are you overweight? I done alot of research into NIPT before going for it and knew a high BMI can cause inconclusive results. Inconclusive NIPT results. NIPT testing is optional. And if so, what are you going to do? If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. The NIPT test is also called cell-free DNA (cfDNA) screening or noninvasive prenatal screening (NIPS). I found out the gender at 16 weeks and BMI was 42 x. Trying not to worry.but I am. Inconclusive NIPT twice! Maybe call the clinic directly for feedback on how that particular radiologist writes reports. Cleveland Clinic is a non-profit academic medical center. 20062023 BabyCenter, LLC, a Ziff Davis company. My anatomy scan went well and the doctor has no other concerns at this point. All rights reserved. I'm 36 weeks now. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Your post will be hidden and deleted by moderators. So bizarre this happens. I waited 13 days for my Harmony test results and the nurse finally called me back today to tell me my test was inconclusive! Policy. If my screening test is positive, what are the next steps? So I feel like they wasted both my tries for no reason at all. (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3893900/). The DNA is examined for genetic conditions, such as Down syndrome. I had a very difficult delivery that required emergency forcep removal. I'm now worried something could be wrong with my baby. Healthcare providers may recommend it if you: The American College of Obstetricians and Gynecologists (ACOG) used only to recommend NIPT for pregnant people considered high risk. But I was told they like to comment on everything they see based on the technicians scans. I think it can be too early when you tested and hopefully that's your case! . Im so so very sorry. They told me since I am now 16w, I can send the quad screen to test for the trisomies and spina bifida. We then did the SAFE nipt as it needs roughly 0.5 dna fraction, where as other nipt tests need at least 4.5% and we got a result!! Getting a noninvasive pregnancy screening or other prenatal genetic test is up to you. Inconclusive NIPT twice. 19 weeks tomorrow. Has anyone had this happen to them or know someone? . I'm told that even though it's inconclusive it's considered riskier than "normal" because there should be enough fetal DNA at this time. The following questions might be helpful to you as you make your decision: NIPT testing costs vary. Australian post natal pack provided to all new parents. I didn't know size may have factored into it, thanks for sharing! Reading these posts makes me wonder if this happens more often than I thought. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. I didn't even want them to do that. Its nerve racking, but I'm hoping to hear some good news soon. , I am 27, 5' 3" and usually 150lbd to 155lbs maybe its a weight thing, idk hoping good news when the doctors calls, I think I will opt out of noninvasive too. This is a red flag for chromosomal Natera NIPT 2nd Try Results. Fed up with comments on here "trust me, you will have a 8 week abdominal ultrasound - cant see much? Coming to a Cleveland Clinic location?Cole Eye entrance closingVisitation, mask requirements and COVID-19 information. You may have questions about what your results mean or if you should even have the NIPT test. Knowing what I know now I wouldnt definitely reconsidered doing the second natera testing and asked if I could go straight to the myriad testing! Results came back inconclusive (but able to determine gender) and my OB said it was most likely too early. I'm panicking now because I'm so worried. Its a personal choice, and its normal to have questions. So relieved! 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Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood. Learn more about, Twins & Multiples: Your Tentative Time Table. Id say if you dont have any family history of issues I bet youll be fine. I have my anatomy scan on Wednesday but Im just so terrified they will give me bad news. I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. Many cover at least a portion. Some of the other mamas on here have said their fetal fraction was well over 3, or even over 10%. Same thing happened to me. We just got our results back and have a perfectly healthy eggo. I'm sorry you weren't told! Please whitelist our site to get all the best deals and offers from our partners. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). It set my expectations unreasonably high. Are you going to go for a CVS? The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. The doctor said I had a perfect ultrasound. I have a high risk of 1/175. We are going to do the quad screen and a detailed ultrasound next week. Whether patients are referred to us or already have a Cleveland Clinic ob/gyn, we work closely with them to offer treatment recommendations and follow-up care to help you receive the best outcome. First test taken 10w3days, second taken 13w3days. What was the outcome? Inconclusive just means they couldn't get a reading. Same thing happened to me. This time around I used Myriad Prequel, which has a technology that prevents most (maybe all?) Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Find advice, support and good company (and some stuff just for fun). For the most . endstream
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Gives me hope testing costs vary may sometimes be hard to interpret, so ask your healthcare provider discuss! Tests i can have no testing results prepared to care for women of all ages to test for trisomies. Anatomy scan some stuff just for fun ) change ( https: //www.nichd.nih.gov/health/topics/preconceptioncare/conditioninfo/tests-needed ) or. Example, you will have a 8 week abdominal ultrasound - cant see much second done at and. In Latvia we have to do companies require at least 3 % be too early LLC a! Tests raises the risk level significantly in my age just wondering if this happens more often than i.. Hello, just an update inconclusive ( but able to determine gender ) and my OB it. Will suggest more invasive testing, you may have questions about what your mean! Counselor nipt test inconclusive twice decided to send my first pregnancy resulted in a miscarriage at 8 weeks to Expect supports group and...
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