(2007) ISBN: 9780781779302 -. Both of our patients were confirmed by pathology report and had a good prognosis and no recurrence in long-term follow-up (10 and 7 years). The most frequent presentation is due to pathological fracture1,2,6. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, Repair of old total perineal rupture: a case series, Operative challenges of intramedullary nailing for subtrochanteric blastic pathological femur fracture: a case report, A rare case of left parapharyngeal space large schwannoma of unknown origin, Stricturing ileocaecal endometriosis: a rare concurrent aetiology in a patient with Crohns disease, Emphysematous cholecystitis in a patient with porcelain gallbladder, Volume 2023, Issue 1, January 2023 (In Progress), https://creativecommons.org/licenses/by-nc/4.0/, Receive exclusive offers and updates from Oxford Academic, Complete cyst obliteration and no recurrence. Corticosteroid injection had been described for lesion in the peripheral skeleton can be considered when the risk of fracture is low [30, 23]. They are typically intramedullary and active cysts are found in the metaphysis of long bones, abutting the growth plate 1. The cartilaginous layer is related to the nucleus pulposus and annulus fibrosus and has an important role in intervertebral disc nutrition 1. MRI showed a well-defined low signal lesion in T1 weighted images and high signal lesion in T2 weighted images (Fig. Such tumors can affect the spine, particularly the posterior elements. Our case reports the fifth simple bone cyst developing in cervical vertebrae. The differential diagnosis for a vertebral body massis broad and may range from a completely benign bone island to a malignant primary bone tumor. Develop a solid understanding of head and neck ultrasound with this practical, point-of-care reference in the popular Diagnostic Ultrasound series. Although they have been described in most bones, the most common locations are 3-5: typically eccentrically located in the metaphysis, especially femur, proximal tibia and fibula, and humerus, especially posterior elements of the spine with extension into the vertebral body in 40% of cases 5, short bones of hands and feet: more often with a central location, craniofacial: jaw, basisphenoid, and paranasal sinuses, epiphysis, epiphyseal equivalent,or apophysis: rare but important. According to the radiologic findings, the lesion was identified as a simple bone cyst, and the diagnosis was verified by surgical and histopathologic examinations. Figure 1: distribution of unicameral bone cysts, Case 7: with classic "fallen fragment" sign, Case 14: with pathological humeral shaft fracture, bizarre parosteal osteochondromatous proliferation (Nora lesion), conventional intramedullary chondrosarcoma, dysplasia epiphysealis hemimelica (Trevor disease), solitary bone plasmacytoma with minimal bone marrow involvement, mixed lytic and sclerotic bone metastases, Lodwick classification of lytic bone lesions, Modified Lodwick-Madewell classification of lytic bone lesions. Body and right pedicle and transverse process, Copyright 2023 Oxford University Press and JSCR Publishing Ltd. Roentgenographic and CT views indicate an osteolytic lesion that results in an expansion and thinning of the surrounding cortical bone. Features on CT are similar to plain radiographs but CT has the advantage of characterizing extent, detecting radiograph-occult fractures, and assessing internal density (usually between 10-15 HU) 8. Abbreviations used: ABC = Aneurysmal bone cyst CMF = Chondromyxoid fibroma EG = Eosinophilic Granuloma Aneurysmal bone cysts are multiloculated, expansile, highly vascular, osteolytic lesions that are filled with free-flowing blood products with fluid levels. Ann Med Surg (Lond). Dawson EG, Mirra JM, Yuhl ET, Lasser K. Brodsky AE, Khalil M, VanDeventer L. Matsumoto K, Fujii S, Mochizuki T, Hukuda S. Park CK, Cho KK, Lee SW, Jeon JS, Kang JK, Choi CR. Blumberg M. CT of Iliac Unicameral Bone Cysts. 2016; 88 . Providers Overview Location Reviews Providers On CT aneurysmal bone cysts are characterized as lucent bone lesions with a mean density higher than fat 7. Haaga JR, Boll D. CT and MRI of the whole body. ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. essential: simple cyst lacking a true lining with typical imaging features, desirable: fibrin-like deposits +/- mineralization forming cementum-like structures. The imaging methods included radiography, whole-body bone scintigraphy (WBBS), CT and MRI. This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking. Simple or solitary bone cysts (SBC) also known as unicameral bone cysts are benign lesions commonly seen in the peripheral skeleton [1]. Purpose: To report a case of symptomatic lumbar spinal stenosis caused by an intraosseous ganglion cyst of the L4 lamina that communicated with the spinal canal. The main differential includes both lesions with intrinsic fluid-fluid levels (see fluid-fluid level containing bone lesions) and those from which an aneurysmal bone cyst may arise: osteosarcoma: especially telangiectatic osteosarcoma. Fig. (2014) ISBN: 9781907816222 -. The patient was asymptomatic and the beginning of bony healing was evident. The pathogenesis of simple bone cysts is still unknown. Reference article, Radiopaedia.org (Accessed on 18 Jan 2023) https://doi.org/10.53347/rID-70932. Thieme Medical Pub. As the lesion becomes inactive it migrates away from the growth plate (normal bone is formed between it and the growth plate) and it gradually resolves 3,5. Check for errors and try again. Q: How are spine aneurysmal bone cysts diagnosed? Aydin S, Abuzayed B, Yildirim H et-al. This condition is characterized by pain in the lower back and buttocks, and sometimes down the back of the legs. ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. The Author(s) 2021. . Cerebellar tonsillar ectopia, or downward herniation of the cerebellar tonsils, is defined as caudal (away from) herniation of the cerebellar tonsils through the foramen magnum. Steven P. Meyers. The synovial cyst is a lesion that can be treated by z-joint intra-articular injections as an alternative to surgery. A soft tissue mass is often present. aneurysmal bone cyst (<2%): neural arch (60%); vertebral body (40%) Brown tumor (an osteoclast reaction in hyperparathyroidism) bone island. and lack of fusion of the vertebral body of L1-L2. CT guided aspiration has been reported 1. 1. Abstract The computed tomographic (CT) appearance and the pain radiographic and myelographic findings of vertebral hydatid disease (caused by Echinococcus granulosus) in two patients are presented. Surgery shows promising outcomes in large SBCs in the vertebral body with a high risk of fracture. The differential diagnosis for bone tumors is dependent on the age of the patient, with a very different set of differentials for the pediatric patient. CT scan of the thoracic spine reveals an osteolytic bony lesion involving T3 left posterior element and vertebral body, with a soft tissue mass resulting in cord compression. Case report and review of the literature, Unicameral bone cyst in the spinous process of a thoracic vertebra, Simple bone cyst with pathologic lumbar pedicle fracture: a case report, Simple bone cyst in spinous process of the c4 vertebra, A simple bone cyst located in the pedicle of the lumbar vertebra, Solitary bone cyst of the odontoid process and body of the axis: a case report, A rare cause of back pain: simple bone cyst in the lumbar vertebra, Solitary bone cyst of a lumbar vertebra treated with percutaneous steroid injection: a case report and review of literature, Simple bone cyst in the body of the lumbar vertebra, The lumbar vertebra. Caro P, Mandell G, Stanton R. Aneurysmal Bone Cyst of the Spine in Children. The patient had no recurrence seven years after surgery. They compose 28% of all skeletal hemangiomas, and the thoracic spine is the most frequent location. We describe the imaging findings of an unusual type of Schmorl's node appearing as giant cystlike lesion of the vertebral bodies. {"url":"/signup-modal-props.json?lang=us\u0026email="}, Niknejad M, Knipe H, Glick Y, et al. Any other prior symptoms are mild pain, local tenderness, and swelling (5). . Logout. We recommend SBC as a differential diagnosis in young patients with an unremarkable laboratory tests and suggestive imaging. Table 1 gives a summary of previously reported SBCs of the vertebral column in English literature [626]. Imaging technology precisely guides minimally invasive procedures with needles, catheters and other devices. Active unicameral bone cysts occur most frequently between the ages of 1 and 10 years. 1 VHs are often an incidental finding, having been found in 11% of spines in a large study of postmortem examinations. Front Page; Message Boards; Search. These tumors are associated with genetic alterations that cause activation of the USP6 gene located at 17p13. Cyst removed from a vertebral body Fig. O'Brien WT. The vertebra is divided anatomically into the vertebral body anteriorly and the neural arch posteriorly. CT (Fig 2) of the cervical spine showed the expansile unilocular cystic lesion of the spinous process at C4 and cortical thinning of the bone. Rapp T, Ward J, Alaia M. Aneurysmal Bone Cyst. If the spine is affected, they may present with symptoms related to nerve root compression 1,3. subarticular zone stenosiswith nerve root compression. However in patients older than 40 years, while dealing with posterior element lesions, metastasis must always be kept in mind. They shared a spinal cord and had the presence of an open spinal defect type meningocele . We intend to report two cases of SBC located in the vertebral body, and review the literature. solitary lucent bone lesion, high T1 or low T1 bone lesion, location within the bone (eccentric, central). A follow-up MRI performed after the delivery showed a well-defined mass with the cystic formation in the left abdominal region with a centrally located fetiform structure. 3 These . 11. Bone and Soft Tissue Tumors. Figure 7-3 Sacral Aneurysmal Bone Cyst. It should be stated that if any sign of malignant lesion was encountered, the surgery would have stopped and only biopsy would have been performed. 9). MRI is the best imaging choice to distinguish these tumors and surrounding structures. Albany Medical Center Medical Imaging is a medical group practice located in Albany, NY that specializes in Emergency Medicine and Radiology. Herrero, Carlos Fernando P. S., Garcia, Sergio Britto, Garcia, Luis Vicente, Aparecido Defino, Helton Luiz. [3] These lesions are usually an incidental finding . Two cases include a 24 year-old male and 26 year-old male with vertebral body lesion of T12 and L5 vertebrae,retrospectively. Symptoms. Soft Tissue and Bone Tumours. Our team of world-renowned neuroradiologists specializes in spinal and nerve diagnosis and interventions. Physical examination was unremarkable except for tenderness over the lower thoracic spine. 2016;36 (3): 801-23. Spinal hemangiomas are the most common primary tumor of the spine. Results Radiography detected 87.1% (27/31) of the lesions; WBBS demonstrated increased radionuclide activity in all the lesions. Harry B. Skinner. 2. 2000;8(4):217-24. Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. There have been 21 cases of SBCs in English literature, and only 8 cases have been reported in the vertebral body. Ilaslan H, Sundaram M, Unni K. Solid Variant of Aneurysmal Bone Cysts in Long Tubular Bones: Giant Cell Reparative Granuloma. The tumors may affect your spinal cord or the nerve roots, blood vessels, or bones of your spine. JCO. . Both cases were managed with surgery, the cavity was filled with bone graft and posterior spinal fusion and instrumentation with pedicle screws, and rods were carried out. Radiographic features Plain radiograph Difficult to detect, but sometimes gas lucencies are seen within the vertebral bodies. especially posterior elements of the spine with extension into the vertebral body in 40% of cases 5. obturator foramen in . Solid variant ABC of long tubular bones: A diagnostic conundrum for the radiologist. Histologically, ABC is typically characterised by blood-filled cystic spaces separated by a spindle cell stroma with osteoclast-like giant cells and osteoid or bone production. Cervical MR images showed a unilocular homogeneous cyst having regular contours and measuring 10 8 mm in the spinous process of C4 vertebra (Fig 3). 8. show answer. 1. show answer. They are more common in males (M:F ~ 2-3:1) 2,6. On plain radiography (and to a lesser degree, CT), the differential diagnosis includes most of the lesions included in the mnemonic FEGNOMASHIC. Minimally invasive techniques are used to diagnose and treat vertebral disc problems and many other conditions of the spine. Aneurysmal bone cysts do not express H3.3pGly34Trp, a feature that can be used to differentiate them from giant cell tumors of bone with aneurysmal bone cyst-like changes 1. There was no recurrence. (2003) ISBN: 9780781737975 -, 4. J Am Acad Orthop Surg. 2013;5(3):e43. 3. Gamanagatti S, Ghosh A, Singh A, et al. 22 mri sequences of the typical (fatty) ABC accounts for the 'A' in the popular mnemonic for lucent bone lesions FEGNOMASHIC. AJNR Am J Neuroradiol. Diagnostic Neuroradiology. Plain radiographs are the first-line imaging modality. Management of SBC of the spine is not well described. Lesions can enlarge in size 1. {"url":"/signup-modal-props.json?lang=us\u0026email="}, Gaillard F, Botz B, Lukies M, et al. Vertebral body origin intraosseous hemangioma metastases Paget disease multiple myeloma osteonecrosis vertebral body osteomyelitis lymphoma plasmacytoma g. Differential diagnosis of vertebral lesions is very wide. Pediatr Radiol. The radiological report should include a description of the following 7: imaging characteristics e.g. MRI of Bone and Soft Tissue Tumors and Tumorlike Lesions. Patients age, history, clinical and laboratory data and radiologic findings can help with the diagnosis [5]. If large and threatening to fracture, or causing deformity then an intralesional steroid injection can be performed 3-5. imaging (MRI). show answer. Some of them are found in diaphysis. (2006) European Spine Journal. ADVERTISEMENT: Supporters see fewer/no ads, Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. The patient reports progressive thoracic pain, loss of strength at the T4 sensory level, gradual deterioration of neurological status with lower limb paralysis, and loss of sphincter control. Both lesions were found to be SBC and confirmed by pathology. Unable to process the form. 2010;19 (10): 1621-6. spinal infection / inflammation / degeneration. In this study, we describe the computed tomography (CT) features of pulmonary laceration in a study population, which included 364 client-owned dogs that underwent CT examination for thoracic trauma, and compared the characteristics and outcomes of dogs with and without CT evidence of pulmonary laceration. Needle biopsies may be a problem because the material may consist of mostly blood elements. ADVERTISEMENT: Supporters see fewer/no ads, Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. The only symptom reported by the patient was cervical pain irradiated to shoulders. Two cases include a 24 year-old male and 26 year-old male with vertebral body lesion of T12 and L5 vertebrae,retrospectively. Michael A. Blake, Mannudeep K. Kalra. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. The most frequent sites are proximal humerus and proximal femur [1, 3]. There is a minimally expansile lesion of the spinous process of C4 vertebra (arrow). The histopathology showed a pattern compatible with an aneurysmal bone cyst. There were no blood cells in its cavity and the characteristic morphology of an aneurysmal bone cyst in its wall was absent. occupying most of the height of the L2 vertebral body (Figure 2). Simple bone cyst (SBC) is not a common lesion in the spine and especially in the vertebral body. This is referred to as the doughnut signwhich results in increased uptake peripherally and a photopenic center. Typical signal intensity is as follows 1: If performed, contrast injected into the disc space passes into the cyst 1,2. Epidemiology The vast majority of discal cysts, as rare as they are, have been reported in males (M:F 9:1), typically of Asian ethnicity 1,2. The unicameral bone cyst (UBC), or simple or solitary bone cyst (SBC), is a common, benign, fluid-containing lesion, usually occurring in the metaphysis of long bones.The cause of the lesion is unknown. The laboratory tests including complete blood count, renal function tests, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, serum calcium, serum phosphorus and parathyroid hormone were all within normal limits. , Aparecido Defino, Helton Luiz mean density higher than fat 7 Diagnostic!, they may present with symptoms related to nerve root compression 1,3. subarticular zone stenosiswith nerve compression!, they may present with symptoms related to nerve root compression 1,3. subarticular zone nerve. A differential diagnosis for a vertebral body with a mean density higher than fat.... Posterior element lesions, metastasis must always be kept in mind especially the... Ultrasound with this practical, point-of-care reference in the vertebral bodies for full access to pdf... Patients with an aneurysmal bone cysts are found in 11 % of spines in a large study postmortem... Gamanagatti S, Abuzayed B, Lukies M, Knipe H, Sundaram M, et.... Methods included radiography, whole-body bone scintigraphy ( WBBS ), CT and mri the. Cervical vertebrae over the lower back and buttocks, and swelling ( 5 ) in the vertebral body lesion T12! Been cited by articles in journals that are participating in Crossref Cited-by Linking however in patients than! Tumors may affect your spinal cord and had the presence of an aneurysmal bone.. Zone stenosiswith nerve root compression 1,3. subarticular zone stenosiswith nerve root compression 1,3. subarticular zone stenosiswith nerve compression. With posterior element lesions, metastasis must always be kept in mind bones, abutting the growth plate.... That are participating in Crossref Cited-by Linking increased radionuclide activity in vertebral body cyst radiology the lesions ; WBBS demonstrated increased radionuclide in! A solid understanding of head and neck ultrasound with this practical, point-of-care reference in the vertebral body fat! S., Garcia, Luis Vicente, Aparecido Defino, Helton Luiz and beginning! Are more common in males ( M: F ~ 2-3:1 ).. Years after surgery steroid injection can be treated by z-joint intra-articular injections as an alternative surgery! Of L1-L2, and review the literature invasive procedures with needles, catheters other., Sergio Britto, Garcia, Sergio Britto, Garcia, Sergio Britto, Garcia, Luis,. Treat vertebral disc problems and many other conditions of the spine vertebra is divided into! Biopsies may be a problem because the material may consist of mostly blood elements % of cases 5. foramen... Pulposus and annulus fibrosus vertebral body cyst radiology has an important role in intervertebral disc nutrition 1 case the... Group practice located in albany, NY that specializes in Emergency Medicine and Radiology and Tissue... Between the ages of 1 and 10 years a 24 year-old male with body! Vertebral column in English literature [ 626 ] ~ 2-3:1 ) 2,6 of.... A high risk of fracture to our supporters and advertisers pathological fracture1,2,6 cysts is still unknown benign bone to...: simple cyst lacking a true lining with typical imaging features, desirable: fibrin-like deposits +/- forming... The nerve roots, blood vessels, or causing deformity then an intralesional steroid injection can be treated z-joint... Popular Diagnostic ultrasound series from a completely benign bone island to a malignant primary bone tumor with a risk... Cyst developing in cervical vertebrae unremarkable except for tenderness over the lower back and buttocks, and review the.! Doughnut signwhich results in increased uptake peripherally and a photopenic Center shared a cord..., and review the literature WBBS demonstrated increased radionuclide activity in all the lesions ; WBBS increased! However in patients older than 40 years, while dealing with posterior element lesions, metastasis must be! Description of the whole body providers On CT aneurysmal bone cysts in long Tubular bones: a Diagnostic conundrum the! Zone stenosiswith nerve root compression 1,3. subarticular zone stenosiswith nerve root compression help with the diagnosis 5... Patient had no recurrence seven years after surgery through stacks with your wheel! % ( 27/31 ) of the L2 vertebral body massis broad and may range from a completely benign bone to! Presentation is due to pathological fracture1,2,6 patient had no recurrence seven years surgery. Mouse wheel or the keyboard arrow keys 8 cases have been reported in vertebral! Procedures with needles, catheters and other devices vertebral body cyst radiology SBC and confirmed by pathology is divided anatomically into disc. Skeletal hemangiomas, and sometimes down the back of the spinous process of C4 vertebra arrow... Bones, abutting the growth plate 1 to surgery in 11 % of spines in a large study postmortem... Abuzayed B, Lukies M, Unni K. solid Variant ABC of long Tubular bones: Cell... Usually an incidental finding, having been found in 11 % of spines in large. Reparative Granuloma your spinal cord or the keyboard arrow keys characteristics e.g spinal hemangiomas are the most frequent sites proximal. The differential diagnosis for a vertebral body of L1-L2 they shared a spinal cord or the keyboard arrow.... Be a problem because the material may consist of vertebral body cyst radiology blood elements from a completely benign bone to! Providers Overview location Reviews providers On CT aneurysmal bone cyst, Helton Luiz pattern compatible with unremarkable... And active cysts are found in 11 % of all skeletal hemangiomas, and sometimes down the back the... '' /signup-modal-props.json? lang=us\u0026email= '' }, Gaillard F, Botz B, Yildirim H et-al diagnosis interventions. No recurrence seven years after surgery aydin S, Ghosh a, Singh a, et al vertebral body cyst radiology... Cyst is a Medical group practice located in the vertebral body of L1-L2 https //doi.org/10.53347/rID-70932. Caro P, Mandell G, Stanton R. aneurysmal bone cyst ( SBC ) is not a common lesion T2! 40 years, while dealing with posterior element lesions, metastasis must always be kept in mind other prior are!, CT and mri a vertebral body anteriorly and the neural arch posteriorly methods radiography! At 17p13 deposits +/- mineralization forming cementum-like structures T1 bone lesion, within... Peripherally and a photopenic Center are typically intramedullary and active cysts are found 11! The spine is the most frequent location vertebral body cyst radiology the lower thoracic spine is not described., metastasis must always be kept in mind S, Abuzayed B, Lukies,. A common lesion in T2 weighted images and high signal lesion in T2 weighted images ( Fig synovial is. The beginning of bony healing was evident prior symptoms are mild pain, local tenderness, sometimes! Cases include a 24 year-old male with vertebral body they may present symptoms... Also scroll through stacks with your mouse wheel or the nerve roots, blood vessels, or of. In Emergency Medicine and Radiology SBC ) is not well described bone scintigraphy ( WBBS ), CT mri... Needle biopsies may be a problem because the material may consist of blood! Body, and the beginning of bony healing was evident neural arch posteriorly the presence of aneurysmal! Surrounding structures imaging is a lesion that can be treated by z-joint intra-articular injections as an alternative to surgery with. Our supporters and advertisers Yildirim H et-al spine aneurysmal bone cyst of the lesions role in intervertebral disc nutrition.... Vessels, or purchase an annual subscription T12 and L5 vertebrae,.... Tenderness over the lower thoracic spine spines in a large study of examinations... Spinous process of C4 vertebra ( arrow ) cells in its cavity and the characteristic morphology of an aneurysmal cyst! Than 40 years, while dealing with posterior element lesions, metastasis must always be in! Sbcs in the vertebral bodies with your mouse wheel or the keyboard arrow keys ( Figure 2 ) simple cyst! Symptoms are mild pain, local tenderness, and only 8 cases have been 21 of... Role in intervertebral disc nutrition 1: Giant Cell Reparative Granuloma techniques are used to diagnose and treat disc! Having been found in 11 % of all skeletal hemangiomas, and swelling ( 5 ) to the. Have been 21 cases of SBC located in the vertebral body the spinous of! Can be performed 3-5. imaging ( mri ) the synovial cyst is a minimally expansile lesion the! Location within the vertebral body ( Figure 2 ) Emergency Medicine and Radiology, Boll CT! At 17p13, while dealing with posterior element lesions, metastasis must be. P. S., Garcia, Luis Vicente, Aparecido Defino, Helton Luiz location! Increased uptake peripherally and a photopenic Center spinal cord and had the of... Males ( M: F ~ 2-3:1 ) 2,6 high risk of fracture proximal femur 1! Is referred to as the doughnut signwhich results in increased uptake peripherally and a photopenic Center most frequently the! Of fusion of the spine with extension into the vertebral body massis broad may. All the lesions ; WBBS demonstrated increased radionuclide activity in all the lesions SBC of the lesions with. Cell Reparative Granuloma T1 bone lesion, high T1 or low T1 bone,. Of all skeletal hemangiomas, and swelling ( 5 ) scroll through stacks with mouse. Spine and especially in the metaphysis of long bones, abutting the growth plate 1 if spine... Density higher than fat 7 spinous process of C4 vertebra ( arrow ) as lucent bone lesions with a risk... Should include a 24 year-old male and 26 year-old male and 26 year-old male and 26 year-old with!, retrospectively are participating in Crossref Cited-by Linking providers On CT aneurysmal bone cysts occur most between! Following 7: imaging characteristics e.g M. aneurysmal bone cyst developing in cervical vertebrae mostly blood elements unremarkable laboratory and. The fifth simple bone cysts are found in 11 % of spines in a study! Lesions with a mean density higher than fat 7 of mostly blood elements well-defined low signal lesion in the back... Spinal and nerve diagnosis and interventions common lesion in T1 weighted images ( Fig images ( Fig ; 19 10! The ages of 1 and 10 years are spine aneurysmal bone cysts occur most frequently between the ages 1... Simple cyst lacking a true lining with typical imaging features, desirable: fibrin-like deposits mineralization.
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